\u3053\u306e\u51ac\u3088\u304f\u3057\u305f\u6599\u7406\u3067\u3001\u934b\u306b\u6839\u83dc\u3001\u304d\u306e\u3053\u985e\u3001\u8449\u91ce\u83dc\u7b49\u3001\u8c5a\u3070\u3089\u8089\u306e\u9806\u306b\u8f09\u305b\u3066\u304a\u9152\u3092\u8089\u306b\u307e\u3093\u3079\u3093\u306a\u304f\u3075\u308a\u304b\u3051\u3066\u30c9\u30fc\u30e0\u306e\u84cb\u3092\u3057\u3066\u4e2d\u706b\u2192\u3068\u308d\u706b\u306b\u304b\u3051\u3066\u304a\u304f\u3060\u3051\u3067\u3059\u3002
\n\u4f55\u5ea6\u304b\u4f5c\u3063\u3066\u3044\u308b\u3068\u3001\u304d\u306e\u3053\u304c\u3068\u3063\u3066\u3082\u304a\u3044\u3057\u3044\u6642\u304c\u3042\u308a\u307e\u3057\u305f\u3002
\n\u4f55\u6545\u304b\u3092\u8abf\u3079\u3066\u307f\u308b\u3068\u3001\u304d\u306e\u3053\u985e\u306f\u300170\u2103\u524d\u5f8c\u304c\u30b0\u30a2\u30cb\u30eb\u9178(*1)\u304c\u5897\u3048\u308b\u6e29\u5ea6\u5e2f\u3067\u3042\u308b\u305d\u3046\u3067\u3059\u3002
\n\u305d\u3053\u306b\u3074\u3063\u305f\u308a\u306f\u307e\u3063\u305f\u6642\u304c\u304a\u3044\u3057\u304b\u3063\u305f\u3088\u3046\u3067\u3059\u3002
\n\u5148\u65e5\u306f\u3001\u3053\u306e\u304a\u3044\u3057\u3044\u304d\u306e\u3053\u4f5c\u308a(\u4eca\u56de\u306f\u3057\u3044\u305f\u3051)\u306b\u6311\u6226\u3057\u3066(*2)\u69d8\u3005\u306a\u6599\u7406\u306b\u304d\u306e\u3053\u3092\u5165\u308c\u3066\u307f\u307e\u3057\u305f\u3068\u3053\u308d\u3001\u3053\u308c\u304b\u3089\u306e\u30b7\u30fc\u30ba\u30f3\u306b\u591a\u65b9\u9762\u3067\u4f7f\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002
\n\u304d\u306e\u3053\u306f\u5e74\u4e2d\u624b\u306b\u5165\u308b\u98df\u6750\u306a\u306e\u3067\u7092\u3081\u7269\u306b\u5165\u308c\u3066\u3082\u3088\u3044\u3057\u3001\u304a\u6d78\u3057\u3001\u548c\u3048\u7269\u7b49\u3082\u3088\u3044\u3067\u3059\u3002<\/p>\n
\u3055\u3066\u6b21\u306b\u590f\u91ce\u83dc\u304c\u305f\u3063\u3077\u308a\u3068\u308c\u308b\u6599\u7406\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n
\u7c21\u5358\u306b\u4f5c\u308c\u308b\u30d8\u30eb\u30b7\u30fc\u306a\u84b8\u3057\u6599\u7406\u3067\u3059\u3002
\n\u590f\u91ce\u83dc\u3092\u84b8\u3057\u3066\u304b\u3089\u3001\u51b7\u3084\u3057\u3066\u98df\u3079\u307e\u3059\u306e\u3067\u3001\u751f\u91ce\u83dc\u306e\u30b5\u30e9\u30c0\u3088\u308a\u3082\u305f\u3063\u3077\u308a\u3068\u91cf\u304c\u53d6\u308c\u307e\u3059\u3002
\n\u672c\u6765\u306a\u3089\u3001\u30b9\u30c1\u30fc\u30e0\u30b1\u30fc\u30b9\u3092\u4f7f\u3063\u3066\u30ec\u30f3\u30b8\u3067\u4f5c\u308b\u3068\u90e8\u5c4b\u304c\u6691\u304f\u306a\u3089\u305a\u306b\u3059\u3080\u306e\u3067\u3059\u304c\u3001\u4eca\u5e74\u306e\u590f\u306f\u3001\u5730\u57df\u306b\u3088\u3063\u3066\u306f\u96fb\u529b\u4e0d\u8db3\u304c\u4e88\u60f3\u3055\u308c\u307e\u3059\u306e\u3067\u52a0\u71b1\u65b9\u6cd5\u306f\u3001\u5404\u81ea\u6700\u9069\u306a\u65b9\u6cd5\u3092\u8003\u3048\u3066\u304f\u3060\u3055\u3044\u3002
\n\u305d\u306e\u6642\u306e\u30bd\u30fc\u30b9\u3067\u3001\u79c1\u306e\u30b9\u30da\u30b7\u30e3\u30eb\u30ec\u30b7\u30d4\u3092\u7d39\u4ecb\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n
\u3010\u84b8\u3057\u91ce\u83dc\u30b9\u30da\u30b7\u30e3\u30eb\u30bd\u30fc\u30b9\u3011
\n\u25cb\u6750\u6599
\n\u3044\u308a\u3054\u307e \u5927\u3055\u3058\uff12
\n\u30de\u30e8\u30cd\u30fc\u30ba \u5927\u3055\u3058\uff11
\n\u7802\u7cd6 \u5927\u3055\u3058\uff11
\n\u30de\u30b9\u30bf\u30fc\u30c9 \u5c0f\u3055\u3058\uff11\u30681\/2
\n\u3057\u3087\u3046\u3086 \u5927\u3055\u3058\uff11
\n\u9162 \u5927\u3055\u3058\uff11
\n\u307f\u308a\u3093 \u5c0f\u3055\u3058\uff11<\/p>\n
\u25cb\u4f5c\u308a\u65b9
\n\u3042\u305f\u308a\u3070\u3061(*3)\u306b\u3054\u307e\u3092\u3044\u308c\u64e6\u308a\u307e\u3059\u3002(\u3053\u3053\u306f\u624b\u3092\u629c\u304b\u306a\u3044)
\n\u6b21\u306b\u66f8\u3044\u3066\u3042\u308b\u9806\u306b\u5165\u308c\u3066\u64e6\u308a\u6df7\u305c\u3066\u3044\u304d\u307e\u3059\u3002
\n\u304a\u5b50\u69d8\u306b\u306f\u3001\u30de\u30b9\u30bf\u30fc\u30c9\u3068\u7802\u7cd6\u306e\u8abf\u6574\u3092\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n
\u3082\u3046\u4e00\u54c1
\n\u3010\u590f\u91ce\u83dc\u306e\u51b7\u305f\u3044\u716e\u7269\u3011
\n\u25cb\u6750\u6599
\n\u203b\u91ce\u83dc\u306e\u5408\u8a08\u91cf\u306f\u3001\u5c0f\u9262\u3067\uff14\uff5e\uff16\u76bf\u7a0b\u5ea6(\u4e2d\u578b\u306e\u934b\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044)
\n\u7389\u306d\u304e
\n\u304b\u307c\u3061\u3083 (\u3042\u307e\u308a\u5927\u304d\u304f\u30ab\u30c3\u30c8\u3057\u306a\u3044)
\n\u306a\u3059 (\u8f2a\u5207\u308a\u306b\u30ab\u30c3\u30c8\u5f8c\u3001\u6c34\u306b\u3064\u3051\u30a2\u30af\u3068\u308a\u3092\u3059\u308b)
\n\u30c8\u30de\u30c8
\n\u305d\u306e\u4ed6\u304a\u597d\u307f<\/p>\n
\u3060\u3057 1\u30ab\u30c3\u30d7(\u3067\u304d\u308c\u3070\u304d\u3063\u3061\u308a\u3068\u3068\u3063\u3066\u307b\u3057\u3044) (*4)
\n\u7802\u7cd6 \u5927\u3055\u3058\uff11\u53c8\u306f\u5927\u3055\u3058\uff11\u30681\/2
\n\u8584\u53e3\u91a4\u6cb9 \u5927\u3055\u3058\u3000\uff13<\/p>\n
\u203b\u91ce\u83dc\u306e\u91cf\u306b\u3088\u308a\u5272\u5408\u5909\u66f4\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n
\u25cb\u4f5c\u308a\u65b9
\n\u6750\u6599\u3068\u8abf\u5473\u6599\u3092\u5165\u308c\u3001\u304b\u307c\u3061\u3083\u304c\u67d4\u3089\u304b\u304f\u306a\u308b\u307e\u3067\u716e\u308b
\n\u7c97\u71b1\u3092\u53d6\u308a\u3001\u4e00\u6669\u51b7\u8535\u5eab\u306b\u5165\u308c\u3066\u3001\u7fcc\u65e5\u51b7\u305f\u3044\u307e\u307e\u76db\u308a\u4ed8\u3051\u308b\u3002<\/p>\n
\u7c21\u5358\u306b\u3067\u304d\u307e\u3059\u306e\u3067\u3001\u66f8\u3044\u3066\u3044\u308b\u3082\u306e\u306b\u4e00\u5de5\u592b\u3057\u3066
\n\u81ea\u5206\u306a\u308a\u306e\u30aa\u30ea\u30b8\u30ca\u30eb\u306b\u6311\u6226\u3057\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n
*1\u3000\u30a6\u30a3\u30ad\u30da\u30c7\u30a3\u30a2\u65e5\u672c\u8a9e\u7248\u3088\u308a
\n\u30b0\u30a2\u30cb\u30eb\u9178(\u30b0\u30a2\u30cb\u30eb\u3055\u3093\u3001guanylic acid)\u306f\u3001\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u69cb\u9020\u3092\u6301\u3064\u6709\u6a5f\u5316\u5408\u7269\u306e\u4e00\u7a2e\u3067\u3042\u308b\u3002
\n\u30b0\u30a2\u30ce\u30b7\u30f3\u4e00\u30ea\u30f3\u9178 (Guanosine monophosphate) \u3068\u3082\u547c\u3070\u308c\u3001GMP\u3068\u7565\u3055\u308c\u308b\u3002
\nGMP\u306f\u6838\u9178\u5869\u57fa\u306e\u30b0\u30a2\u30cb\u30f3\u3001\u4e94\u70ad\u7cd6\u306e\u30ea\u30dc\u30fc\u30b9\u30011\u3064\u306e\u30ea\u30f3\u9178\u3088\u308a\u69cb\u6210\u3055\u308c\u3066\u304a\u308a\u3001\u30ea\u30f3\u9178\u3068\u30b0\u30a2\u30ce\u30b7\u30f3(\u30cc\u30af\u30ec\u30aa\u30b7\u30c9)\u306e\u9593\u3067\u30ea\u30f3\u9178\u30a8\u30b9\u30c6\u30eb\u3092\u5f62\u6210\u3057\u3066\u3044\u308b\u3002
\n\u30ea\u30f3\u9178\u30a8\u30b9\u30c6\u30eb\u306e\u4f4d\u7f6e\u306b\u3088\u308a\u30012′-\u4f53\u30013′-\u4f53\u30015′-\u4f53\u304c\u77e5\u3089\u308c\u308b\u3002
\n5′-\u4f53\u306fRNA\u4e2d\u306e\u90e8\u5206\u69cb\u9020\u3068\u3057\u3066\u73fe\u308c\u3001\u5448\u5473\u6027\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3068\u3057\u3066\u3082\u7528\u3044\u3089\u308c\u308b\u3002<\/p>\n
\u5229\u7528 [\u7de8\u96c6]5′-GMP\u306f\u30b7\u30a4\u30bf\u30b1\u306e\u65e8\u5473\u6210\u5206\u3067\u3042\u308a\u5de5\u696d\u7684\u306b\u751f\u7523\u3055\u308c\u3066\u3001\u6838\u9178\u7cfb\u8abf\u5473\u6599\u3068\u3057\u3066\u5229\u7528\u3055\u308c\u308b\u3002
\n\u6838\u9178\u7cfb\u8abf\u5473\u6599\u306e\u591a\u304f\u306f\u30ab\u30c4\u30aa\u30d6\u30b7\u306e\u65e8\u5473\u6210\u5206\u3067\u3042\u308b5′-IMP\u30685′-GMP\u306e\u6df7\u5408\u7269\u3067\u3042\u308a\u3001\u5de5\u696d\u7684\u306b\u306f\u9175\u6bcdRNA\u3092\u539f\u6599\u306b\u3057\u3066\u3001\u30a2\u30aa\u30ab\u30d3\u306e\u30cc\u30af\u30ec\u30a2\u30fc\u30bcP1(EC. 3.1.30.1)\u3092\u4f5c\u7528\u3055\u305b\u30665′-GMP\u30685′-AMP\u306e\u6df7\u5408\u7269\u306b\u3057\u3001\u30b3\u30a6\u30b8\u83cc\u306eAMP\u30c7\u30a2\u30df\u30ca\u30fc\u30bc\u30675′-AMP\u306e\u307f\u30925′-IMP\u306b\u8ee2\u63db\u3057\u3066\u9175\u7d20\u7684\u306b\u6838\u9178\u7cfb\u8abf\u5473\u6599\u3092\u88fd\u9020\u3057\u3066\u3044\u308b\u3002<\/p>\n
*2 \u4f4e\u6e29\u84b8\u3057\u304c\u3067\u304d\u308b\u3000\u3072\u3089\u3084\u307e\u84b8\u3057\u934b\u3000\u3068\u8a00\u3046\u3082\u306e\u3082\u8ca9\u58f2\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n
*3 \u3059\u308a\u9262\u306e\u3053\u3068\u3092\u5927\u962a\u3067\u306f\u3042\u305f\u308a\u3070\u3061\u3068\u3082\u8a00\u3044\u307e\u3059\u3002<\/p>\n
*4 \u3060\u3057\u3092\u3068\u308c\u3070\u3001\u5869\u5206\u304c\u5c11\u306a\u304f\u3066\u3082\u5927\u4e08\u592b\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
\u3053\u306e\u51ac\u3088\u304f\u3057\u305f\u6599\u7406\u3067\u3001\u934b\u306b\u6839\u83dc\u3001\u304d\u306e\u3053\u985e\u3001\u8449\u91ce\u83dc\u7b49\u3001\u8c5a\u3070\u3089\u8089\u306e\u9806\u306b\u8f09\u305b\u3066\u304a\u9152\u3092\u8089\u306b\u307e\u3093\u3079\u3093\u306a\u304f\u3075\u308a\u304b\u3051\u3066\u30c9\u30fc\u30e0\u306e\u84cb\u3092\u3057\u3066\u4e2d\u706b\u2192\u3068\u308d\u706b\u306b\u304b\u3051\u3066\u304a\u304f\u3060\u3051\u3067\u3059\u3002 \u4f55\u5ea6\u304b\u4f5c\u3063\u3066\u3044\u308b\u3068\u3001\u304d\u306e\u3053\u304c\u3068\u3063\u3066\u3082\u304a\u3044\u3057\u3044\u6642\u304c\u3042\u308a\u307e\u3057\u305f\u3002 \u4f55…\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[11],"tags":[],"_links":{"self":[{"href":"https:\/\/e-delico.co.jp\/index.php?rest_route=\/wp\/v2\/posts\/876"}],"collection":[{"href":"https:\/\/e-delico.co.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/e-delico.co.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/e-delico.co.jp\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/e-delico.co.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=876"}],"version-history":[{"count":2,"href":"https:\/\/e-delico.co.jp\/index.php?rest_route=\/wp\/v2\/posts\/876\/revisions"}],"predecessor-version":[{"id":1338,"href":"https:\/\/e-delico.co.jp\/index.php?rest_route=\/wp\/v2\/posts\/876\/revisions\/1338"}],"wp:attachment":[{"href":"https:\/\/e-delico.co.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=876"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/e-delico.co.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=876"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/e-delico.co.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}